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Psychedelic mushroom

Albert Hoffmann, who worked at the Swiss pharmaceutical company Sandoz, was looking for a drug that promoted blood circulation. Then, in 1938, he developed a synthetic substance called Lysergic Acid Diethylamide, which did not have much of the therapeutic effect he had hoped for. However, about five years later, he accidentally discovered the extraordinary efficacy of this synthetic substance. Hoffman, who “accidentally ingested a small amount one day” of the neglected product, “realized that he had created something powerful, and he was both horrified and amazed.”

 

In Central America, wild Psychedelic mushrooms grow, which the Aztecs called ‘Teonanacatl.’ It means ‘Flesh of the Gods.’ They had “ceremonial use” of “this inconspicuous little brown mushroom.” The Spanish Catholics who conquered this place in the 16th century banned ‘magic mushrooms’, so it took about 400 years for them to become known to the world. “In 1955, Gordon Watson, a Manhattan banker and amateur mycologist, tasted these magic mushrooms in a village in southern Mexico.” Two years later, he published a 15-page account of his experience in the weekly magazine ‘Life’, informing the world of “mushrooms that cause strange illusions.” The substance extracted from this mushroom is called ‘Psilocybin.’

 

Michael Pollan (66), an American nonfiction writer and journalist, unexpectedly published a book about LSD and psilocybin. The original book was published in the United States in 2018. Pollan is considered a very well-known author in Korea through books such as “The Omnivore’s Dilemma,” “The Desiring Plant,” and “Second Nature.” He has dealt with a variety of subjects such as nature, gardens, plants, and food. However, the fact that he devoted his writerly attention to drugs that were considered ‘narcotics’ or ‘hallucinogens’ is quite unusual. In his book, he refers to LSD and psilocybin collectively as ‘psychedelics.’ I do not agree with the term ‘hallucinogen’. He explains, “The word ‘psychedelic,’ coined in 1956, is etymologically accurate,” adding, “This word, taken from Greek, means ‘Mind Manifesting.’”

 

As he confesses, the author is not part of the ‘psychedelic generation.’ He was born in 1955 and entered college in the 1970s, so he admits that he spent his youth “in an era when fear-mongering stories about LSD were rampant.” In his late 20s, he confessed that “the only psychedelic experience I had was two or three times using magic mushrooms,” and that “after enduring nausea for a while, I enjoyed four or five hours of hallucinations that were like a nice italicized version of a familiar reality.” . Of course, it was the ‘timid experience’ of an ordinary young man. Rather than “an experience of complete dissolution of the self,” it was “just a low-volume aesthetic experience.”

 

The author, who believed that “matter is the fundamental element of the world and that everything can be explained by physical laws,” confesses that it was only when he was approaching 60 that he “seriously thought about trying LSD for the first time.” Of course, there are many reasons for this. One day at a dinner party, a woman sitting at the end of the table was telling her audience about her acid trip (her hallucinatory experience) and said, “My husband and I do LSD regularly to keep her intellectually stimulated. “It helps our work quite a bit,” she said. “It turned out that she was a renowned psychologist.” Of course, what prompted the author to further open his mind to psychedelics was a paper by a research team at Johns Hopkins University. “I was completely fascinated by the paper. “Their study demonstrated that high doses of psilocybin can be safely and reliably used to produce mystical experiences.”

 

The book describes the history of psychedelics, various controversies, and the medical benefits that have been emerging one after another from various angles. The content and results of research conducted at not only Johns Hopkins, but also Imperial College London, UC Berkeley, and Mount Sinai Icahn School of Medicine are introduced. Researchers and therapists are also interviewed. However, the most interesting point is the author’s actual experience of “turning the handle and stepping inside.” Although the book appears to be an objective document about psychedelics, the author's experiences and thoughts unfold as expressions such as ‘I,’ ‘in my opinion,’ and ‘from what I have experienced’ appear frequently. He also describes the “overwhelming hallucinations” and “completely open dream-like state” he experienced.

 

According to the authors, “Most of the notorious hazards are exaggerated or untrue. It is virtually impossible to die from an overdose of LSD or psilocybin, and neither drug is addictive.” Rather, she “treats depression and addiction” and “offers true insight” through “expansion of consciousness.” It could also “improve healthy people” as a kind of “mental gym”. Of course, the author emphasizes that this insight or improvement does not come from the drug itself, but “comes from our mind.” “Psychedelics just opened the door.”

 

At the end of the book, the author says, “I sincerely hope that psychedelics will one day be more widely available and not limited to sick people.” But there is a clue. “It’s not that I just want it to be legalized,” he said, pointing out, “It’s also true that people who use psychedelics tend to do stupid and dangerous things.” This is a warning against a so-called ‘bad trip’. This is also the reason why “careful clinical screening” and “assistance from experienced guides” are mentioned. The author defines this book as “the story of the renaissance of LSD and psilocybin.”


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Psychedelic Mushroom

Psilocybe cubensis

Singer noted that Psilocybe cubensis had psychoactive properties in 1949.

In Australia, the use of psychoactive mushrooms grew rapidly between 1969 and 1975.

In a 1992 paper, locals and tourists in Thailand were reported to consume P. cubensis and related species in mushroom omelets—particularly in Ko Samui and Ko Pha-ngan. At times, omelets were adulterated with LSD, resulting in prolonged intoxication. A thriving subculture had developed in the region. Other localities, such as Hat Yai, Ko Samet, and Chiang Mai, also had some reported uغير مجاز مي باشدe.

In 1996, jars of honey containing Psilocybe cubensis were confiscated at the Dutch-German border. Upon examination, it was revealed that jars of honey containing psychedelic mushrooms were being sold at Dutch coffee shops.

P. cubensis is probably the most widely known of the psilocybin-containing mushrooms used for triggering psychedelic experiences after ingestion. Its major psychoactive compounds are:

Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine)
Psilocin (4-hydroxy-N,N-dimethyltryptamine)
Baeocystin (4-phosphoryloxy-N-methyltryptamine)
Norbaeocystin (4-phosphoryloxytryptamine)
Aeruginascin (N,N,N-trimethyl-4-phosphoryloxytryptamine)
The concentrations of psilocin and psilocybin, as determined by high-performance liquid chromatography, are in the range of 0.14–0.42% (wet weight) and 0.37–1.30% (dry weight) in the whole mushroom 0.17–0.78% (wet weight) and 0.44–1.35% (dry weight) in the cap, and 0.09%–0.30% (wet weight) and 0.05–1.27% (dry weight) in the stem, respectively.[17] For quickly and practically measuring the psychoactive contents of most healthy Psilocybe cubensis varieties, it can generally be assumed that there is approximately 15 mg (+/- 5 mg) of psilocybin per gram of dried mushroom.[18] Furthermore, due to factors such as age and storage method, the psilocybin and psilocin content of a given sample of mushrooms will vary.

Individual body composition, brain chemistry and psychological predisposition play a significant role in determining appropriate doses. For a modest psychedelic effect, a minimum of one gram of dried Psilocybe cubensis mushrooms is ingested orally, 0.25–1 gram is usually sufficient to produce a mild effect, 1–2.5 grams usually provides a moderate effect and 2.5 grams and higher usually produces strong effects.[19] For most people, 3.5 dried grams (1/8 oz) would be considered a high dose and may produce an intense experience; this is, however, typically considered a standard dose among recreational users. Body composition (usually weight) should be taken into account when calculating doغير مجاز مي باشدe. For many individuals, doses above three grams may be overwhelming. For a few rare people, doses as small as 0.25 gram can produce full-blown effects normally associated with very high doses. For most people, however, that dose level would have virtually no effects.

There are many different ways to ingest Psilocybe cubensis. Users may prefer to take them raw, freshly harvested, or dried and preserved. It is also possible to prepare culinary dishes such as pasta or tea with the mushrooms. However, the psychoactive compounds begin to break down rapidly at temperatures exceeding 100 °C (212 °F).[20] Another method of ingestion known as "Lemon Tekking" involves combining pulverized Psilocybe cubensis with a concentrated citrus juice with a pH of ~2. Many users believe that a considerable amount of the psilocybin will have been dephosphorylated into psilocin, the psychoactive metabolite, by citric acid. However, this claim is not substantiated by the literature on the metabolism of psilocybin, as dephosphorylation is known to be mediated by the enzyme alkaline phosphatase in humans.[21] It is therefore more likely that citric acid mostly helps in breakdown of mushroom cells, aiding in digestion and psilocybin release.[citation needed] The "Lemon Tekk" method of consumption results in a more rapid onset and can offer easier digestion or reduced "come-up pressure" associated with raw consumption.[22] Psilocybe cubensis can also be taken in conjunction with other botanicals such as turmeric, ginger, and black pepper. A 2019 study observed turmeric to act as a mild MAOI, which, when combined with psilocin, potentiates the biochemical interactions between serotonin receptors and psilocin, creating an entourage effect.

Upon ingestion, effects usually begin after approximately 20–60 minutes (depending on the method of ingestion and stomach contents) and may last from four to ten hours, depending on doغير مجاز مي باشدe and individual biochemistry. Visual distortions often occur, including walls that seem to breathe, a vivid enhancement of colors, and the animation of organic shapes.[citation needed]

The effects of high doses can be overwhelming depending on the particular phenotype of cubensis, grow method, and the individual. It is recommended not to eat wild mushrooms without properly identifying them as they may be poisonous. In particular, similar species include mushrooms of the genus Galerina and Pholiotina rugosa—all potentially deadly—and Chlorophyllum molybdites. All of these grow in pastures, a similar habitat to that preferred by P. cubensis.

 


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